Responses of adrenal sympathetic preganglionic neurons to stimulation of cardiopulmonary receptors.
نویسندگان
چکیده
The current study examined whether or not the activation of Bezold-Jarisch reflex with administration of phenylbiguanide (PBG, 100 microg/kg) into right atrium elicits differential responses in the two populations of adrenal sympathetic preganglionic neurons (SPNs) regulating the release of epinephrine (EPI ADR SPNs) and norepinephrine (NE ADR SPNs), respectively, from adrenal medullary chromaffin cells. Extracellular activity of 48 adrenal SPNs in the intermediolateral cell column (IML) were recorded in urethane/chloralose-anesthetized rats. Twenty-three EPI ADR SPNs and 25 NE ADR SPNs were antidromically activated by stimulation of left adrenal nerve and orthodromically activated by rostral ventrolateral medulla (RVLM) stimulation. At a mean arterial pressure (MAP) of 99. 6+/-2.8 mmHg, the mean spontaneous discharge rates of EPI ADR SPNs and NE ADR SPNs were 6.2+/-0.5 and 4.3+/-0.5 spikes/s, respectively. Intra-atrial PBG markedly inhibited 96% of EPI ADR SPNs (by 3.8+/-0. 4 spikes/s; n=22) and 76% of NE ADR SPNs (by 2.9+/-0.5 spikes/s; n=19) with hypotensive responses (DeltaMAP=33.2+/-5.3 and 26.4+/-5.0 mmHg, respectively). The remaining SPNs were weakly excited or unaffected. We conclude that both groups of SPNs regulating catecholamine release are primarily inhibited by stimulation of cardiopulmonary receptors and that these responses parallel the sympathoinhibitory and hypotensive components of the Bezold-Jarisch reflex.
منابع مشابه
Glutaminergic receptors in rostral ventrolateral medulla mediate the cardiovascular responses to activation of bed nucleus of the stria terminalis in female rats
The bed nucleus of the stria terminalis (BST) has been known to contain estrogen (E)-concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of glutamate antagonist receptors in the rostral ventrolateral medulla (RVL...
متن کاملGlutaminergic receptors in rostral ventrolateral medulla mediate the cardiovascular responses to activation of bed nucleus of the stria terminalis in female rats
The bed nucleus of the stria terminalis (BST) has been known to contain estrogen (E)-concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of glutamate antagonist receptors in the rostral ventrolateral medulla (RVL...
متن کاملGABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat
The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...
متن کاملGABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat
The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...
متن کاملEffect of GABAA Receptors in the Rostral Ventrolateral Medulla on Cardiovascular Response to the Activation of the Bed Nucleus of the Stria Terminalis in Female Ovariectomized Rats
Background: The areas of the bed nucleus of the stria terminalis (BST) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST. Methods: Experiments were done in α-ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Brain research
دوره 887 1 شماره
صفحات -
تاریخ انتشار 2000